- Sanders, Barry
- Sanders, Deion
- Sands, Terdell
- Sapp, Warren
- Saturday, Jeff
- Sciullo, Steve
- Scott, Chad
- Seau, Junior
- Sehorn, Jason
- Seymour, Richard
- Sharpe, Shannon
- Sheppard, Lito
- Shiancoe, Visanthe
- Shipp, Marcel
- Shockey, Jeremy
- Sims, Ryan
- Smith, Akili
- Smith, Brady
- Smith, Bruce
- Smith, Emmitt
- Smith, Robert
- Sowell, Jerald
- Spikes, Takeo
- Staley, Duce
- Steussie, Todd
- Stevens, Matt
- Stewart, James
- Stewart, Kordell
- Stinchcomb, Matt
- Stokley, Brandon
- Stover, Matt
- Strahan, Michael
- Streets, Tai
- Stubblefield, Dana
- Swayne, Kevin